Abstract The influence of surface distribution was incorporated with the configuration of charged DNA
chains to propose a new theoretical model to quantitatively describe both complete and incomplete hybrid-
ization induced deflections. The deflection radius of curvature was treated as the only variable for the DNA
detection. Predictions on relations between cantilever deflection and the incomplete DNA hybridization
given by the proposed model could perfectly match experiments of reference . The prediction accura-
cy could even allow the detection of changes in a single base pair. The model developed in this work
may help decipher the familiar mismatch phenomenon in DNA-based disease detections.
Fund:Supported by Natural Science Foundation of China (11421062, 11472119); the Fundamental Research Funds for the
About author:: ：Wang Ji-zeng (1974-), male, born in Hejian, Hebei Province, professor, doctor, e-mail: firstname.lastname@example.org, majoring
in cellular biomechanics and wavelet method, corresponding author.